Epidermal Growth Factor Receptor (EGFR) (E746-A750del) (SP111)

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WB Image for Root Catalog#M411
Human lung carcinoma stained with anti-EGFR (del) antibody
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Human lung carcinoma stained with anti-EGFR (del) antibody

Human lung carcinoma stained with anti-EGFR (del) antibody

QuantityCatalog No.VolumeDilutionPrice
M41117.0ml $596

EGFR is a transmembrane tyrosine kinase that belongs to the HER/erbB protein family. Somatic mutations in the tyrosine kinase domain of EGFR are present in a subset of lung adenocarcinoma. Two types of mutations account for approximately 90% of mutant cases: a specific point mutation L858R which occurs in exon 21 and short in-frame deletions in exon 19. A common lesion in exon 19 is the deletion of E746-A750, although other variants can also occur.

Product Specification Sheets:

M411(EGFR exon 19)_RUO_E.pdf

Product Details:

  • TechnologyRabbit Monoclonal
  • Clone NameSP111
  • ApplicationIHC-P
  • Species Reactivity
  •   TestedHu
  •   Predicted by homologyN/A
  • IsotypeRabbit IgG
  • ImmunogenE746-A750del specific
  • Cellular LocalizationCytoplasm, Membrane
  • Control TissueLung Carcinoma with E746-A750 Deletion
  • Regulatory RatingResearch Use Only (RUO)
  • Entrez
  • Storage Requirement2-8°C
  • Target Molecular Weight175 kDa
  • FormulationRefer to Data Sheet