N-Ras (Q61R) (SP174)

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Western Blot analysis of SK-MEL-2 cell lysate with N-Ras (Q61R) antibody
SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody
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SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody

SK-MEL-2 cells stained with anti-N-Ras (Q61R) antibody

QuantityCatalog No.VolumeDilutionPrice
M47417.0ml $441

GTPase N-Ras or N-Ras is a guanine-nucleotide binding protein. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the MAPK signal pathway. Point mutations (Q61R) in Ras prevent the GAP-mediated inhibition of the MAPK pathway in certain cancers such as lung carcinoma and melanoma. Abnormal MAPK signaling may lead to uncontrolled cell proliferation, resistance to both apoptosis and cancer therapy. **Please contact us for availability**

Product Specification Sheets:

M474(N-RAS Q61R)_RUO_B.pdf

Product Details:

  • TechnologyRabbit Monoclonal
  • Clone NameSP174
  • ApplicationIHC-P, WB
  • Species Reactivity
  •   TestedHu
  •   Predicted by homologyN/A
  • IsotypeRabbit IgG
  • ImmunogenSynthetic peptide of human N-Ras protein containing N-Ras (Q61R) point mutation.
  • Cellular LocalizationMembrane
  • Control TissueSK-MEL-2 Cell Line
  • Regulatory RatingResearch Use Only (RUO)
  • Entrez4893
  • Storage Requirement2-8°C
  • Target Molecular Weight21 kDa
  • FormulationRefer to Data Sheet