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Human kidney stained with anti-SPARC (clone SP205) antibody

SPARC (SP205)




Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin (ON), or basement-membrane protein 40 (BM-40), is a glycoprotein expressed in osteoblasts, endothelial cells, antigen presenting cells, stromal fibroblasts, spermatocytes, steroid-producing cells of the adrenal glands, and glomeruli of the kidney. It is up-regulated in many solid tumors such as astrocytoma, glioma, and osteosarcomas, and the stroma of many solid tumors from colon, lung, breast, and pancreas.




Human small intestine stained with anti-Smooth Muscle Myosin Heavy Chain (clone SP314) antibody

Smooth Muscle Myosin Heavy Chain (SP314)




Human smooth muscle myosin heavy chain (SMMHC) is part of smooth muscle hexameric myosin protein and it is used as a marker for smooth muscle cells and their tumors. It is also expressed in myoepithelial cells of the breast.




Human prostate stained with anti-PSA (clone SP317) antibody

PSA (SP317)




Prostate specific antigen (PSA) is a member of the kallikrein family of serine proteases expressed in the prostate epithelium and in the majority of prostate carcinomas. Low level of PSA is occasionally expressed in breast, endometrium, salivary gland tumors, adrenal neoplasms, and renal cell carcinomas.




Human stomach stained with anti-Gastrin (clone SP318) antibody

Gastrin (SP318)




Gastrin is a peptide hormone released from G cells by peptide stimulation in the pyloric antrum of the stomach. It stimulates parietal cells to secret gastric acid in the stomach.




Human breast carcinoma stained with anti-Mammaglobin A (clone SP319) antibody

Mammaglobin A (SP319)




Mammaglobin-A is a breast glycoprotein expressed in breast and some breast carcinomas. It is also expressed in the epithelial cells of the apocrine and eccrine sweat glands, and in the minority of pulmonary adenocarcinoma and endometrial carcinoma.




Human ovarian cancer stained with anti-Wilms' Tumor 1 (clone SP320) antibody

Wilms' Tumor 1 (WT1) protein (SP320)




Wilms tumor protein (WT1) is a gene involved in the induction of Wilms’ tumor from kidney of children. WT1 has been identified in fallopian tube, kidney, testis, proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, rhabdomyosarcoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor.




Human ovarian cancer stained with anti-Wilms' Tumor 1 (clone SP321) antibody

Wilms' Tumor 1 (WT1) protein (SP321)




Wilms tumor protein (WT1) is a gene involved in the induction of Wilms’ tumor from kidney of children. WT1 has been identified in fallopian tube, kidney, testis, proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, rhabdomyosarcoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor.




Human testis stained with anti-Inhibin alpha (clone SP323) antibody

inhibin alpha (SP323)




Inhibin-alpha is expressed in limited normal and neoplastic tissues and can be used as a marker of adrenal cortical neoplasms and gonadal sex-cord stromal tumors. It is expressed in placenta, testis, adrenal cortex, adrenal cortical tumors adrenocortical tumor, sex cord stromal tumors of the ovary (such as granulosa cell tumor), trophoblastic tumors, and minority of endometrial carcinoma, prostate carcinoma, hemangioblastoma, and lung carcinoma.




Human bone marrow stained with anti-CD61 (clone SP324) antibody

CD61 (SP324)




Integrin beta-3 (ITGB3), also known as CD61, is expressed in human platelets, megakaryocytes, and their malignancies such as megakaryoblastic leukemia.




Human breast ductal carcinoma stained with anti-Phospho ERK (Thr202, Tyr204) (clone SP327) antibody

Phospho ERK 1/2 (Thr202, Tyr204) (SP327)




The p44/42 MAPK (Erk1/2) is a member of mitogen-activated protein kinases (MAPKs) involved in serine/threonine protein kinases signaling pathway. It can be activated by cytokines, growth factors, and mitogens or inhibited by a family of dual-specificity (Thr/Tyr) MAPK phosphatases or MEK inhibitors. The protein expression of pERK1/2 (pT202/pY204) is frequently elevated in cancer.




Human breast ductal carcinoma stained with anti-Beta-Catenin (clone SP328) antibody

Beta-Catenin (SP328)




Beta-catenin interacts with E-cadherin for maintaining the epithelial integrity. Mutations and overexpression of β-catenin are associated with various tumors from breast, colon, cervix, liver, ovary and endometrium. Beta-catenin and E-cadherin are sometime used for the distinction of ductal vs. lobular carcinoma of the breast since majority of invasive ductal carcinomas shows β-catenin membranous expression, whereas invasive lobular carcinomas lacks β-catenin expression.




Human tonsil stained with anti-Lysozyme (clone SP329) antibody

Lysozyme (SP329)




Lysozyme is a glycoside hydrolase found in myeloid cells, histiocytes, granulocytes, macrophages, monocytes, and some cancer cells. It is used to identify histiocytic neoplasia and lymphoproliferative disorders.




Human tonsil stained with anti-LAG3 (clone SP346) antibody

LAG3 (SP346)




Lymphocyte activation gene 3 protein (LAG3) is one of inhibitory receptors on activated T cells. The binding of LAG3 with its binding peptide can lead to negative regulation of T cell function. LAG3 may also express in some activated B cells, NK cells, and plasmacytoid dendritic cells.




Human renal cell carcinoma stained with anti-PAX8 (clone SP348) antibody

PAX8 (SP348)




Paired box protein Pax-8 (Pax­8) is a "paired box" transcription factors involved in normal thyroid development and kidney cell differentiation. PAX8 is highly expressed in renal cell carcinomas, ovarian non-mucinous carcinoma, and thyroid follicular carcinomas.




Human testis stained with anti-NY-ESO-1 (clone SP349) antibody

Ny-ESO-1 (SP349)




Cancer/testis antigen 1, also known as NY-ESO-1, is mainly expressed in testis, ovary, placenta, uterus, and a wide variety of cancers from lung, esophageal, liver, gastric, prostate, ovarian, bladder, and melanoma.




Human tonsil stained with anti-Lysozyme (clone SP350) antibody

Lysozyme (SP350)




Lysozyme is a glycoside hydrolase found in myeloid cells, histiocytes, granulocytes, macrophages, monocytes, and some cancer cells. It is used to identify histiocytic neoplasia and lymphoproliferative disorders.




Human lung adenocarcinoma stained with anti-Phospho-EIF4G (clone SP351) antibody

Phospho EIF4G (Ser1108) (SP351)




Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is a scaffold protein involved in bringing mRNA to the ribosome for translation initiation. The carboxy-terminal region of eIF4G contains several phosphorylation sites at Ser1108, Ser1148, and Ser1192. The level of expression of phospho-eIF4G (Ser1108) is up-regulated in some cancers from breast, colon, prostate, and lung.




Human lung squamous cell carcinoma stained with anti-Phospho EGFR (clone SP353) antibody

Phospho EGFR (Tyr1092) (SP353)




Epidermal growth factor Receptor (EGFR) is a receptor for epidermal growth factor (EGF) and related growth factors. EGFR is involved in the control of cell growth and differentiation. EGFR is overexpressed in many solid tumors from breast, lung, colon, head and neck, and other organs. The antibody is designed to bind to mature human EGFR with phosphor-tyrosine at 1068 position.




Human tonsil stained with anti-CTLA4 (clone SP355) antibody

CTLA4 (SP355)




Cytotoxic T-lymphocyte protein 4 (CTLA4), also known as CD152, is a protein receptor on the surface of activated T-cells. CTLA4 binds to CD80 (B7-1) and CD86 (B7-2) on the cell surface of antigen presenting cells to down-regulate T cell function.